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Home Disease Index Sarcoidosis
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Overview

Causes
Symptoms
Risk Factor

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Overview

 


Sarcoidosis is a disease that usually strikes in the lungs, although other organs, the skin, the lymph nodes, the heart, the spleen, the liver, the pancreas, the eyes, and the nervous system may also be involved. It is a disease of the connective tissue which is accompanied by an increase of calcium in the blood. The cause is unknown but it could be connected to environmental factors and there is a slight risk that it is hereditary. The disease usually resolves itself spontaneously. It strikes men and women equally between the ages of 20 and 50.



Causes

 

The cause of the disease is unknown. Tissue samples from affected organs show clusters of immune cells (macrophages, lymphocytes, and multinucleated giant cells). These clusters are called granulomas.

Possible causes include a hypersensitive response to some factor in the environment, a genetic predisposition, or an extreme immune response to infection. The incidence varies widely according to race and sex.

 



Symptoms

 

There are often no symptoms and the diagnosis may be made coincidentally after an X-ray examination of the chest.

When there are symptoms they typically include: general unease, slight fever, weight loss, breathlessness, trouble with the joints, sore spots on the skin, and infections that affect the iris of the eyes.



Risk Factors

 

Anyone, of any race or age, can develop sarcoidosis. But the following factors make it more likely you'll get the disease:

Race : Black Americans are far more likely to develop sarcoidosis than are white Americans. And although sarcoidosis affects white men and women about equally, black women get the disease twice as often as black men do.
Ethnicity : People of Scandinavian, German or Irish descent have an increased risk.
Age : Sarcoidosis normally occurs between the ages of 20 and 40. It rarely affects children, but can occur in adults older than 50.

   


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