is caused by an infection with the bacterium Salmonella typhi, which is only found in humans and may lead to serious illness. When the bacterium passes down to the bowel, it penetrates through the intestinal mucosa (lining) to the underlying tissue. If the immune system is unable to stop the infection here, the bacterium will multiply and then spread to the bloodstream, after which the first signs of disease are observed in the form of fever. The bacterium penetrates further to the bone marrow, liver and bile ducts, from which bacteria are excreted into the bowel contents. In the second phase of the disease the the immune tissue of the small intestine, and the often violent small-bowel symptoms begin. is caused by Salmonella paratyphi, a similar and generally milder disease.The term 'murine typhus' is used for salmonella in animals. |