urinary tract infection treatment
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Home Disease Index Urinary tract infection (UTI)

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Overview

Causes
Symptoms

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What is urinary tract infection?

 


Urinary tract infection (UTI) is defined as the presence of multiplying micro-organisms (bugs) in the tract through which urine flows from the kidneys via the bladder to the outside world. UTI is 50 times more common in women, with about 5 per cent per year developing symptoms. UTI is uncommon in men below 60 years of age, but the frequency is similar in men and women in older age groups. The condition ranges from cystitis (a mild but distressing inflammation that is limited to the bladder) to severe infections of the kidney such as pyelonephritis (when the infection has reached the kidney tissue itself). Therapy depends on how and why the infection shows itself. Most patients respond rapidly to antibiotic therapy and are unlikely to have any other urinary tract abnormality.



What causes UTI?

 


In healthy men, urine is sterile (contains no micro-organisms). The most important factor in maintaining the sterility of the urinary tract is emptying the bladder completely and frequently. The cause of most UTIs is bacteria that initially settle (colonise) around the urethra (urine tube), and then ascend into the rest of the urinary tract. Several factors can make this process more likely to occur.

Obstruction:
enlarged prostate
gland urethral
stricture (narrowing).

Neurological conditions:
spina bifida
multiple sclerosis
spinal cord injury.
Structural bladder disease:
diverticula (s
mall sacs or bulges) in the bladder wall
tumour.

Abnormal urine drainage:
horseshoe kidney
obstruction by kidney or bladder stones
polycystic kidney
bladder reflux disease (usually due to leaky valves between the bladder and ureter
tubes that connect to the kidneys).

Foreign body:
instrumentation (ie during a procedure)
catheters and st
ents.

Underlying disease:
diabetes
steroid therapy
.

UTIs are classified as either community acquired or hospital acquired. 70 per cent of infections are community acquired, usually caused by the bacteria Escherichia coli (E coli) from the patient's own bowels.

Hospital acquired infections are usually E. Coli but Pseudomonas and Staphlococc i are important causes, particularly when a surgical instrument such as a catheter is used, instrumentation is the predisposing factor. Hospital infections can often be due to multiple organisms, and antibiotic resistance is a common problem.



What are the symptoms of UTI?

 


Symptoms differ, depending on whether the infection affects the lower (bladder and urethra) or upper (kidneys and ureters) parts of the urinary tract. The symptoms of lower urinary tract infectoin are dysuria (burning on passing urine), frequency (frequent need to pass urine) and urgency (compelling need to urinate). The urine can be cloudy with an offensive odour. In older men, generalised symptoms such as confusion and incontinence can be present. Urine infections are much commoner in the elderly, due to poor bladder emptying, an enlarged prostate, or incontinence associated with stroke or dementia.

The symptoms of upper urinary tract infection are the same as lower tract symptoms plus loin (flank) pain, fever and chills. The patient is likely to be ill and might require hospital admission.



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