child growth hormone deficiency
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Home Disease Index Growth hormone deficiency

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Overview

Causes
Symptoms
Risk Factor

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Overview

 

Growth hormone deficiency can be both a total or a partial condition, resulting in impaired physical development.

The growth hormone is one of the hormones produced in the pituitary gland (hypophysis), a small gland situated on the underside of the brain. Secretion of the growth hormone is controlled by other hormones released by a different part of the brain. When the growth hormone enters the bloodstream it stimulates the liver to secrete yet another hormone, 'insulin-like growth factor' (primarily IGF-1).

The elderly naturally produce less growth hormones than young adults.




Causes

 

There are several possible mechanisms that result in a growth hormone deficiency:

  • insufficient release of stimulatory hormone from the hypothalamus.
  • insufficient production of growth hormone by the pituitary.
  • decrease in IGF-1 hormones.
  • problems can also be caused by defects in the receptors that 'receive' the hormone in the body's cells.

There are many possible causes for a growth hormone deficiency including:

  • very rarely it may be due to a genetic defect, which in some instances may also be hereditary.
  • a lack of oxygen at birth.
  • diseases in the pituitary gland, the brain or the liver.
  • abnormalities in the hormone receptors.
  • an autoimmune attack.
  • however, more often than not, there is no single, clear explanation.
If the pituitary gland function is abnormal, the production of several other types of pituitary hormone may also be reduced, leading to other conditions.

 



Symptoms

 A total growth hormone deficiency is often discovered in a child's infancy. At birth, the infant's height and weight are normal. However, between three to nine months the child's growth rate will be reduced (growth disturbance). Later, the ability to gain weight begins to diminish; teeth development is delayed and the child may also acquire a thick layer of fat under the skin. This symptom will not always be visible if the growth hormone deficiency is only partial.


Risk Factors

 

  

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