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| | | | Home Disease Index Crohn's disease
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 | Overview |
| | Alternative Names Inflammatory bowel disease; Regional enteritis; Ileitis; Granulomatous ileocolitis. This is a disease which causes stomach pains, diarrhoea, and weight loss. The disease is characterised by periods of activity and remissions. It typically affects the lower part of the small intestine (ileum) or the large intestine (colon), but it can affect any part of the digestive system. The affected areas become red and swollen and ulceration may occur. As the ulcers heal, the formation of scar tissue makes the intestine increasingly narrow, leading to obstruction. There is no cure for , but the symptoms can be treated and the periods of remission can be made to last several years. |
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 | Causes |
| | The cause of is unknown, but it tends to be more common in relatives of patients with . The disease typically begins between the ages of 20 and 30. Autoimmune disorders occur when the immune system attacks the body's own cells. In , these rogue immune cells attack the gastrointestinal system. The cause is unknown, but genetic factors seem to play a role. Inflammation frequently occurs at the end of the small intestine that joins the large intestine, but the condition may affect any area of the digestive tract. As a result of the immune attack, the intestinal wall becomes thick, and deep ulcers may form. In addition to the bowel abnormalities, can also affect other organs in the body, causing: Skin rash Fistulas (abnormal connections between bowel and adjacent organs or skin) Liver inflammation Joint disease (arthritis) Eye inflammation Kidney stones Clotting problems (deep vein thrombosis).
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 | Symptoms |
 | Risk Factors |
| | The may occur at any age, but adolescence and early adulthood are the periods of highest risk. The only known risk factors include a family history of Crohn's disease, Jewish ancestry, and smoking. About 7 out of every 100,000 people will develop Fistulas in the following areas: Bladder Vagina Skin -
Abscess Nutritional deficiencies (particularly vitamin B12 deficiency) Complications of corticosteroid therapy Inflammation of the joints Erythema nodosum Pyoderma gangrenosum Lesions in the eye Impaired growth and sexual development in children.
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