uterine cancer treatment
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Home Disease Index Cancer of the Uterus
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Overview

Causes
Symptoms
Risk Factor

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Overview

 

The uterus (womb) is a muscular organ within the pelvis. It has a cavity in the middle which is lined with tissue called the endometrium. Until the menopause, the endometrium builds up every month and is passed during a woman's period. Cancer of the uterus may develop if there are changes in the cells of endometrium during the last few years before the menopause or in the years just after. Cancer of the uterus should not be confused with cervical cancer, which is an entirely different condition.




Causes

 

Endometrial cancer is the most common type of uterine cancer. Although the exact cause of endometrial cancer is unknown, increased levels of estrogen appear to have a role. One of estrogen's normal functions is to stimulate the buildup of the epithelial lining of the uterus. Excess estrogen administered to laboratory animals produces endometrial hyperplasia and cancer.

It is still uncertain what makes the mucous membrane grow and become malignant (cancerous). Some risk factors for the development of this cancer exist including being overweight.

Having children tends to reduce a woman's risk of this disease. Correctly prescribed hormone replacement therapy (HRT) does not cause cancer of the uterus.

Cancer of the uterus is rarely seen in women under 40 and is far more common in women over 60.

 



Symptoms

 

This will vary according to whether or not the woman is still having periods. If she is still having periods then the cancer may make her periods more irregular or heavier. If her periods have stopped, then any bleeding from the vagina is abnormal and cancer of the womb needs to be considered as a possibility.

Any woman past the menopause should consult her doctor immediately if she has sudden and unexpected vaginal bleeding. The fact that cancer of the uterus often develops very slowly should not lead any woman to take any unexpected bleeding lightly.

 

Risk Factors

 

Increased risk is also associated with the following:

  • Nulliparity (never having carried a pregnancy)
  • Infertility (inability to become pregnant)
  • Early menarche (onset of menstruation)
  • Late menopause (cessation of menstruation).

Women who have a history of endometrial polyps or other benign growths of the uterine lining, postmenopausal women who use estrogen-replacement therapy (specifically if not given in conjunction with periodic progestin), and those with diabetes are also at increased risk.

Tamoxifen, a drug used to treat breast cancer, may also increase the risk of developing endometrial cancer.

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